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• Adding a progestogen to estrogen-only therapy greatly reduces this this increased risk.
• HRT may add further to this risk.
• Breast cancer A randomised placebo-controlled trial, the Women’s Health Initiative study WHI and epidemiological studies, including the Million Women Study MWS, have reported an increased risk of breast cancer in women taking oestragens, estrogen-progestogen combinations or tibolone for HRT for several years See Section 4.
• Through its effects on the coagulation system, ethinylestradiol may reduce the effects of anticoagulants such as warfarin, phenindione or nicoumalone.
• G03CA01 Mechanism of action The active ingredient, ethinylestradiol, is chemically and biologically identical to endogenous human oestradiol.

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